원저 : 한국인 구강암 환자에서 인유두종 바이러스의 발현율 분석
분야
의약학 > 기초치의학
저자
김현수 ( Hyun Soo Kim ) , 서미현 ( Mi Hyun Seo ) , 김성민 ( Soung Min Kim ) , 조영아 ( Young Ah Cho ) , 이석근 ( Suk Keun Lee ) , 이종호 ( Jong Ho Lee ) , 명훈 ( Hoon Myoung )
발행기관
대한악안면성형재건외과학회
간행물정보
대한악안면성형재건외과학회지 2013년, 제35권 제4호, 227~235페이지(총9페이지)
파일형식
0s102317.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    High risk human papillomavirus (HPV) is the main source of cervical cancer, nearly up to 100%. Because there are no affordable data regarding the incidence of HPV in different sites of oral cavity, the purpose of this study is to review the previous article and to find out about the incidence and types of HPV in specific areas of oral cavity. Methods: We examined a total of 106 patients with oral cavity cancer for HPV detection. Available DNA chip (MY-HPV chip kitⓡ, Mygene Co., Korea) was used for the detection of low risk HPV types (6, 11, 34, 40, 42, 43, 44) and high risk HPV types (16, 18, 31, 33, 35, 39, 45, 51, 52, 54, 56, 58). Patients were previously diagnosed as invasive cancer of oral cavity. Specimen used for HPV detection was extracted from the main mass during resection and were tested for HPV type, performed by a DNA chip method. Results: Histologic results showed that there were squamous cell carcinomas, mucoepidermoid carcinomas, cystadenocarcinomas, leiomyosarcoma and etc. Among HPV positive cancer, 2 patients showed positive for high risk HPV type 16, 3 patients showed positive for low risk HPV type 6 and the other 2 patients were positive for other types of HPV. Of the 7 patients with HPV positive, 4 patients were on the tongue, 3 on the lower gingiva. Conclusion: Most of the HPV positive cancers were on the tongue in our study. Cervical cancer of HPV infection is reported to be increasing in our society and because HPV infection largely spreads by sexual contact, the incidence of oral cancer with HPV infection is greatly assumed to be on the increase, simultaneously. Because the incidence of HPV on specific areas of oral cavity among oral cancer patients is not identified, more studies are ongoing.
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