원보 : 해면으로부터 분리된 Bromotopsentin의 항산화활성
분야
의약학 > 약화학
저자
이만기 ( Man Gi Lee ) , 김동규 ( Dong Kyoo Kim )
발행기관
한국생약학회
간행물정보
생약학회지 2013년, 제44권 제3호, 224~229페이지(총6페이지)
파일형식
05005077.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Bromotopsentin (BSM) is a bisindole alkaloid compound, which is recognized as a metabolite of the marine sponge Spongosorites sp. In this study, the antioxidant activity of BSM was investigated. The 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay, the trolox equivalent antioxidant capacity (TEAC) assay, the superoxide radical scavenging (NBT) assay, the lipid peroxidation and hydroxyl radical-induced DNA damage assays were carried out to evaluate the antioxidant activity of BSM. It was found that BSM had stronger scavenging activity on the stable free radical DPPH and superoxide radical than L-ascorbic acid with an IC50 value of 62 and 64 μM, respectively. The TEAC value which indicated the total antioxidant capacity of BSM was about 0.8, which was also stronger than L-ascorbic acid. About 1.3 μM of BSM induced 50% inhibition of lipid peroxidation. 60 nM of BSM exhibited a significant protective activity against DNA strand scission by hydroxyl radical on pBR322 DNA. Taken together, we suggest that BSM possesses strong antioxidant activity, and could be a valuable new addition to the list of anti-aging chemotherapeutic agents.
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