원보 : 유산균 발효 천마의 수면유도 효과
분야
의약학 > 약화학
저자
이경호 ( Keyong Ho Lee ) , 이기형 ( Ki Hyeong Rhee ) , 김병수 ( Byung Soo Kim ) , 최영호 ( Yong Ho Choi ) , 김충환 ( Choong Hwan Kim )
발행기관
한국생약학회
간행물정보
생약학회지 2013년, 제44권 제3호, 281~285페이지(총5페이지)
파일형식
05005086.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Ethanol extract of Gastrodia elata fermented with Lactobacillus brevis was highly effective on the duration of pentobarbital hypnosis in mice. Pretreatment of mice with ethanol extract of the fermented Gastrodia elata (200 mg/kg, p.o.) prolonged markedly the duration of pentobarbital sleeping time and reduced the sleep latency. The mechanism of the extract of the fermented Gastrodia elata was investigated to inhibit the binding of 3 H-Flumazenil, a selective benzodiazepine receptor antagonist, to benzodiazepine receptor of mice cortices. IC50 value from displacement of 3 H-Flumazenil binding was 62 μg/mL at the treatment of the fermented Gastrodia elata. Therefore, these finding, such as increase of sleeping time and reduction of sleep latency, was examined by elevated concentration of GABA and parishin C, which were increased by Lactobacillus brevis.
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