There is a clear trend in the 21st century for regional organizations to multiply, to become more multifunctional and most groups address themselves to the reduction of conflict and to transnational challenges such as terrorism. Multilateralism is an ideology “designed” to promote multilateral activity. Multilateralism is an institutional form that coordinates relations among three or more states on the basis of generalized principles of conduct. As an organizing principle, the institution of multilateralism is distinguished from other institutional forms by three properties: indivisibility, generalized principles of conduct, and diffuse reciprocity. The earliest multilateral arrangements instituted in the modern era were designed to cope with the international consequences of the novel principle of state sovereignty. The Shanghai Cooperation Organization(SCO) origins go back to the long tension between the Soviet Union and the People` Republic of China over their shared border, which became a multilateral issue with the independence of the former Soviet Central Asian republics in 1991. The purpose of this study is to analyze the Shanghai Cooperation Organization(SCO) in the context of practicability and Uncertainty. The theoretical frame of this study is based on the theory of multilateralism.