Original Articles : Neuroendocrine Differentiation in Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor
분야
의약학 > 내과학
저자
( You Jin Chang ) , ( Seon Ye Kim ) , ( Yun Jung Choi ) , ( Kwang Sup So ) , ( Jin Kyung Rho ) , ( Woo Sung Kim ) , ( Jae Cheol Lee ) , ( Jin Haeng Chung ) , ( Chang Min Choi )
발행기관
대한결핵 및 호흡기학회
간행물정보
Tuberculosis and Respiratory Diseases 2013년, 제75권 제3호, 95~103페이지(총9페이지)
파일형식
0y910148.pdf [무료 PDF 뷰어 다운로드]
  • ※ 본 자료는 참고용 논문으로 수정 및 텍스트 복사가 되지 않습니다.
  • 구매가격
    4,500원
    적립금
    135원 (구매자료 3% 적립)
    이메일 발송  스크랩 하기
    자료 다운로드  네이버 로그인
    영문초록
    Background:Smallcelllungcancer(SCLC)transformationduringepidermalgrowthfactorreceptortyrosinekinaseinhibitor(EGFR-TKI)treatmentinlungcancerhasbeensuggestedasoneofpossibleresistancemechanisms.Methods:WeevaluatedwhetherSCLCtransformationorneuroendocrine(NE)differentiationcanbefoundinthecelllinemodel.Inaddition,wealsoinvestigateditseffectonresponsestoconventionalchemotherapeuticdrugsoftheSCLCtreatment.Results:ResistantcelllinestovariouskindsofEGFR-TKIssuchasgefitinib,erlotinib,CL-387,785andZD6474withA549,PC-9andHCC827lungadenocarcinomacelllineswereestablished.Amongthem,tworesistantcelllines,A549/GR(resistanttogefitinib)andPC-9/ZDR(resistanttoZD6474)showedincreasedexpressionsofCD56whileincreasedsynaptophysin,Rb,p16andpoly(ADP-ribose)polymerasewerefoundonlyinA549/GRinwesternblotting,suggestingthatNEdifferentiationoccurredinA549/GR.A549/GRcellsweremoresensitivetoetoposideandcisplatin,chemotherapeuticdrugsforSCLC,comparedtoparentalcells.TreatmentwithcAMPandIBMXinducedsynaptophysinandchromograninAexpressioninA549cells,whichalsomadethemmoresensitivetoetoposideandcisplatinthanparentalcells.Furthermore,wefoundatissuesamplefromapatientwhichshowedincreasedexpressionsofCD56andsynaptophysinafterdevelopmentofresistancetoerlotinib.Conclusion:NEdifferentiationcanoccurduringacquisitionofresistancetoEGFR-TKI,leadingtoincreasedchemosensitivity.
    사업자등록번호 220-87-87785 대표.신현웅 주소.서울시 서초구 방배로10길 18, 402호 대표전화.070-8809-9397
    개인정보책임자.박정아 통신판매업신고번호 제2017-서울서초-1765호 이메일 help@reportshop.co.kr
    copyright (c) 2009 happynlife. steel All reserved.