Case Reports : Isolated Cervical Lymph Node Sarcoidosis Presenting in an Asymptomatic Neck Mass; A Case Report
분야
의약학 > 내과학
저자
( Yong Shik Kwon ) , ( Hye In Jung ) , ( Hyun Jung Kim ) , ( Jin Wook Lee ) , ( Won Il Choi ) , ( Jin Young Kim ) , ( Byung Hak Rho ) , ( Hye Won Lee ) , ( Kun Young Kwon )
발행기관
대한결핵 및 호흡기학회
간행물정보
Tuberculosis and Respiratory Diseases 2013년, 제75권 제3호, 116~119페이지(총4페이지)
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0y910151.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Sarcoidosis, a systemic granulomatous disease of unknown etiology. The presentation of sarcoidal granuloma in neck nodes without typical manifestations of systemic sarcoidosis is difficult to diagnose. We describe the case of a 37-year-old woman with an increasing mass on the right side of neck. The excisional biopsy from the neck mass showed noncaseating epithelioid cell granuloma of the lymph nodes. No evidence of mycobacterial or fungal infection was noted. Thoracic evaluations did not show enlargement of mediastinal lymph nodes or parenchymal abnormalities. Immunohistochemistry showed abundant expression of tumor necrosis factor-α in the granuloma. However, transforming growth factor-β was not expressed, although interleukin-1β was focally expressed. These immunohistochemical findings supported characterization of the granuloma and the diagnosis of sarcoidosis. Sarcoidosis can present with cervical lymph node enlargement without mediastinal or lung abnormality. Immunohistochemistry may support the diagnosis of sarcoidosis and characterization of granuloma.
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