Objectives: The aim of this study was to examine anti-thrombotic effect of traditional herbal extracts in a rat model of ferric chloride (FeCl3)-induced carotid arterial thrombosis. Methods: Thirty minutes prior to a 35% FeCl3 application, Sprague Dawley(SD) rats were injected with the 10 types of traditional herbal extracts (100mg/kg, intraperitoneal injection), respectively. The effect of these herbal extracts was examined for time to occlusion(TTO) using the Laser doppler flow meter and measured for thrombus weight (TW) in FeCl3-induced thrombosis model. Results: In the TTO, Salvia miltiorrhiza (Sm, 2.30±0.28 min, p<0.001) and Santalum album (Sa, 2.19±0.19 min, p<0.001) showed significantly delayed TTO more than twice compared with Saline-treated group. Cnidium officinale (Co), Psoralea corylifolia (Pc), Scutellatia baicalensis (Sba), Panax notoginseng (Pn), Angelica tenuissima (At), Scrophularia buergeriana (Sbu), Rhus verniciflua (Rv) and Picrasma quassioides (Pq), except for Rhus verniciflua (Rv) also meaningfully impeded TTO more than one fold. In addition, Salvia miltiorrhiza, Santalum album, Cnidium officinale, Psoralea corylifolia and Scutellatia baicalensis significantly reduced TW more than 10% compared with Saline-treated group. Especially, Salvia miltiorrhiza and Santalum album showed the most excellent anti-thrombotic effect among the 10 herbal extracts tested on the restoration of altered TTO and TW. Conclusions: These results suggest that Sm and Sa extracts have outstanding anti-thrombotic effect in FeCl3-induced thrombosis model and is potentially useful as herbal medicines for the treatment and prevention of thrombosis.
[영남대]나무의이해 족보, 중간기말 정리또는 시험문제 있습니다.
[간호학] 간피상 package
[뇌졸중] 뇌졸중의 개념, 발생인자, 종류와 뇌졸중의 증상, 진단 및 뇌졸중의 치료, 뇌졸중의 재활 그리고 뇌졸중의 예방에 관한 분석
[뇌졸중] 뇌졸중의 정의, 원인, 종류와 뇌졸중의 위험인자, 증상 및 뇌졸중의 발생비율, 진단 그리고 뇌졸중의 치료, 뇌졸중의 예방에 관한 분석
[간호학] 한방 -수면장애
[한의학] 수면장애에 대한 한방적 접근
[기능성식품] 마늘에 대해서
[영남대] 건강다이어트와 비만관리 입니다. -중간기말- 퀴즈 포함입니다.