발효처리한 당귀의 항알레르기 효능에 대한 연구
분야
의약학 > 기초한의학
저자
서민준 ( Min Jun Seo ) , 박진한 ( Jin Han Park ) , 이제현 ( Je Hyun Lee )
발행기관
대한본초학회
간행물정보
대한본초학회지(본초분과학회지) 2013년, 제28권 제5호, 39~44페이지(총6페이지)
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35301294.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Objectives: Allergy is an immune dysfunction caused by degranulation from mast cells in the early phase of allergic disease. The purpose of this study was to investigate the anti-allergic effect of fermented Angelicae gigantis Radix in human mast cell line, HMC-1. Method: The Angelicae gigantis Radix was fermented by Lactobacillus acidophilus. The cell toxicity of fermented Angelicae gigantis Radix(FAGR) was determined by MTT assay. The release of β-hexosaminidase from HMC-1 stimulated by phorbol-12-myristate 13-acetate (PMA) plus A23187 was determined by β -hexosaminidase assay. Also, the concentrations of cytokines (interleukin-1β, -6, -8 and tumor necrosis factor-alpha) were measured by enzyme-linked immunosorbent assay. The gene expression of COX-2 from HMC-1 stimulated by phorbol-12-myristate 13-acetate (PMA) plus A23187 was determined by reverse transcription polymerase chain reaction. The release of histamine on substance P-stimulated HMC-1 was measured by histamine assay. Result: The FAGR suppressed the release of β-hexosaminidase, a marker of degranulation, from HMC-1 stimulated by PMA plus A23187. The FAGR inhibited the production of interleukin-1β, -6, -8 and tumor necrosis factor-alpha. The FAGR inhibited the expression of COX-2 mRNA. The FAGR suppressed the release of histamine on substance P-stimulated HMC-1. Conclusion: These results provide that FAGR may be beneficial in the treatment of allergic inflammatory disease.
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