黃芩(황금) 발효 추출물이 LPS로 유발된 마우스대식세포에서 염증인자증가에 미치는 영향
분야
의약학 > 기초한의학
저자
양회정 ( Hoi Jeong Yang ) , 한효상 ( Hyo Sang Han ) , 이영종 ( Young Jong Lee )
발행기관
대한본초학회
간행물정보
대한본초학회지(본초분과학회지) 2013년, 제28권 제5호, 45~52페이지(총8페이지)
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35301295.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Objectives: This study aims at examining the immuno-modulating activity in the fermentative extract of the root of Scutellaria baicalensis Georgi (Scutellariae Radix) on the production of inflammatory mediator in LPS-stimulated RAW264.7 mouse macrophages. Method : Measurements were done for the influences on the cell viability, generation of hydrogen peroxide in cells and nitric oxide (NO) generation using the macrophage of mouse with the specimen SBS as the fermentative extract of Scutellariae Radix (SBS) with Saccharomyces cerevisiae STV89. Result: As a result of carrying out MTT assay to check the cellular toxicity of the fermentative extract of Scutellariae Radix, any excessive toxicity to the macrophage did not occur from treatments by concentration for SBS. SBS increased the generation of hydrogen peroxide in the macrophage. SBS suppressed the NO generated in macrophages and SBS concentration higher than 25 ㎍/mL significantly suppressed the increased NO generated in LPS-stimulated macrophages. SBS concentration higher than 25 ㎍/mL significantly suppressed the generation of IL-6, IL-10, IL-12p40 and MCP-1 in LPS-stimulated macrophages. Conclusion: Our findings indicate that SBS has an immuno-modulating activity in macrophage activation through suppressing the generation of inflammatory substances, NO, IL-6, IL-10, IL-12p40 and MCP-1.
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