Streptozotocin으로 유도된 당뇨 흰쥐에서 하소에 사용되는 한약의 항당뇨 효과 비교 연구
의약학 > 기초한의학
오태우 ( Tae Woo Oh ) , 강석용 ( Seok Yong Kang ) , 김경호 ( Kyung Ho Kim ) , 송미영 ( Mi Young Song ) , 박용기 ( Yong Ki Park )
대한본초학회지(본초분과학회지) 2013년, 제28권 제5호, 53~60페이지(총8페이지)
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    Objectives: To prove the channel-tropism theory in herbology, we investigated the anti-diabetic effect of six herbal plants used for lower wasting-thirst in streptozotocin-induced diabetic rats. Methods: Diabetes was induced in male Sprague-Dawley rats by consecutive injection of streptozotocin (30 mg/kg i.p.) for 5 days. The rats were divided into normal control, diabetic control, and diabetic treatment with Lycii Radicis Cortex (LRC, 300 ㎎/㎏); Corni Fructus (CF, 300 ㎎/㎏); Bombyx Batryticatus (BB, 50 ㎎/㎏); Lycii Fructus (LF, 300 ㎎/㎏); Phellodendri Cortex (PC, 300 ㎎/㎏); Epimedii Herba (EH, 300 ㎎/㎏); and glibenclimide (10 ㎎/㎏) as a reference drug. Herbal extracts or reference drug were administered orally for 28 days. The changes of body weight, food intake and water intake, and serological markers such as blood glucose, serum total cholesterol, triglyceride (TG), blood urea nitrogen (BUN), and creatinine (Cr) were measured. Results: The decrease of body weight and the increase of food and water intake in STZ-induced diabetic rats was improved by the administration of CF and LF. Also, the enhancement of blood glucose and serum total cholesterol, TG, BUN and Cr in STZ-induced diabetic rats was significantly inhibited by the administration of CF, BB, LF and glibenclimide. On the other hand, EH strongly inhibited the increase of BUN and Cr in the sera of STZ-induced diabetic rats. Conclusions: These results suggest that among six herbal medicines used lower emaciation of emaciation-thirst disease, CF, BB, LF and EH show a characteristics including the channel-tropism theory.
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