木槿花(목근화) 물추출물의 항염효능에 관한 연구
분야
의약학 > 기초한의학
저자
이동민 ( Dong Min Lee ) , 한효상 ( Hyo Sang Han ) , 이영종 ( Young Jong Lee )
발행기관
대한본초학회
간행물정보
대한본초학회지(본초분과학회지) 2013년, 제28권 제5호, 61~68페이지(총8페이지)
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35301297.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Objectives: Hibisci Flos has long been used for inflammatory diseases in traditional Korean medicine. However, little scientific investigation has been carried out. The aim of the present study is to investigate the effect of Hibisci Flos water extract (HF) on inflammatory cytokines production in Raw 264.7 cells stimulated by lipopolysaccaride (LPS). Method: HF was prepared by extracting with boiling water for 2 hours. We observed the cell viability of mouse macrophage Raw 264.7, the production of nitric oxide (NO) and the inflammatory cytokines such as interleukin (IL)-4, IL-5, IL-10, IL-15, tumor necrosis factor-α (TNF-α), interferon-gamma (IFN-γ), vascular endothelial growth factor (VEGF), granulocyte macrophage-colony stimulating factor (GM-CSF), and macrophage colony-stimulating factor (M-CSF) in Raw 264.7 cells stimulated by LPS. Result: The MTT assay was carried out to check the cellular toxicity of HF. No significant toxicity was observed in the experiment. HF significantly inhibited the increase of NO in the macrophages induced by LPS after 24 hour treatment. HF significantly inhibited the production of IL-4, IL-5, IL-10, IL-15, TNF-α, IFN-γ, VEGF, GM-CSF and M-CSF in the Raw 264.7 cells induced by LPS in the concentration of 25 ㎍/mL or higher. Conclusion: These results suggest that HF might have regulatory effects on LPS-induced inflammatory cytokine production, which might explain its beneficial effect in the treatment of inflammatory disease.
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