지유(地楡)의 화장품 소재로서의 약리활성에 관한 연구
분야
의약학 > 기초한의학
저자
장영아 ( Young Ah Jang ) , 김영훈 ( Young Hun Kim ) , 신재천 ( Jae Cheon Shin ) , 한상익 ( Sang Ik Han ) , 이진태 ( Jin Tae Lee )
발행기관
대한본초학회
간행물정보
대한본초학회지(본초분과학회지) 2013년, 제28권 제5호, 79~85페이지(총7페이지)
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35301299.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Objectives: This study was aimed at producing emulsion by using butanol fractions of Sanguisorbae radix(SRA-B) which have high antioxidative and anti-inflammatory actions, and then evaluating stabilities of the emulsion. Methods: We measured antioxidant efficacy of SRA-B by using DPPH assay. Also, we checked the expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) by using the Western blot to evaluate the anti-inflammatory effects of SRA-B3. We prepared emulsion containing SRA-B3(E-SRA-B3) and analysed its particle size distribution under a microscope. Also, we performed the test for stability of the emulsion. Results: SRA-B3 showed the highest efficacy in electronic donating abilities` activity. The Western blot`s results indicated that the protein expression`s amount of iNOS and COX-2 in macrophage stimulated by LPS were reduced by SRA-B3 treatment. The average particle size of E-SRA-B3 was 5~6㎛ in diameter and was 6.7㎛ in a view of the particle distribution. For a period of a observation, E-SRA-B3 has not made particular changes with storage temperature. It was observed that E-SRA-B3 could preserve its stable condition without a particular difference of viscosity during 28 days. Conclusions: From the above results, it was confirmed that SRA-B3 has potentiality enough to be applied to industrialization and could be utilized as antioxidative natural materials and anti-inflammatory cosmetics.
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