Objectives: Herbal medicines were used a lot in the Northeast Asia, traditionally. However, the pharmacopoeia standards in South Korea, China, Japan, Taiwan, and North Korea including many other Asia are different and cause confusion. If the origins are not belonging to same genus, it should be careful to distinguish. In this study, herbal medicines in the pharmacopoeia were analyzed for different genus of origins in order to identify the disruptive items for each country. Methods: The scientific names of herbal medicines (plant based) was analyzed origins from Pharmacopoeias of Republic of Korea, People`s Republic of China, Japan, Taiwan, and Democratic People`s Republic of Korea. The origins specified differently were examined. Especially, the items which have different genus were analyzed in detail and confirmed for correct scientific name. Results: The analyzed herbal medicines in Pharmacopoeia were all 753 items. 320 items were in only one country`s Pharmacopoeia. 237 items were in more than two countries` Pharmacopoeia, but their origins were same on each other. The items which have different genus were 35 items. Conclusions: In general, species belonging to the same genus have similar ecological, morphological, and pharmacological activity. However, species with different genus may have different medicinal ingredients and pharmacological activity. Thus, the items which have same name but different genus are required to analyze for comparison of pharmacological activity. Also, other species belonging to the different genus should be used for different items.