CD83 expression induced by CpG-DNA stimulation in a macrophage cell line RAW 264.7
분야
자연과학 > 화학
저자
( Min Chul Park ) , ( Dong Bum Kim ) , ( Young Hee Lee ) , ( Hyung Joo Kwon )
발행기관
생화학분자생물학회(구 한국생화학분자생물학회)
간행물정보
BMB Reports 2013년, 제46권 제9호, 448~453페이지(총6페이지)
파일형식
02618271.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    CpG-DNA has various immunomodulatory effects in dendritic cells, B cells, and macrophages. While induction of cytokines by CpG-DNA has been well documented in macrophages, the expression of costimulatory molecules in CpG-DNA treated macrophages has not yet been defined. Therefore, we investigated the effects of CpG-DNA on the expression of costimulatory molecules in RAW 264.7 cells. The surface expression of CD80 was slightly increased and CD83 expression was significantly increased in response to CpG-DNA. However, the expression of CD86 and MHC class II was not changed. As expression of CD83 mRNA was also increased by CpG-DNA, CD83 expression is regulated at a transcriptional level. To understand the contribution of signaling pathways to CD83 induction, we used pathway specific inhibitors. The NF-κB inhibitor significantly reduced surface expression of CD83 as well as phagocytic activity of RAW 264.7 cells. Therefore, CD83 expression may contribute to the immunostimulatory effects of CpG-DNA in macrophage cells. [BMB Reports 2013; 46(9): 448-453]
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