Review Article : Regulation of aquaporin-2 in the kidney: A molecular mechanism of body-water homeostasis
분야
의약학 > 내과학
저자
( Tae Hwan Kwon ) , ( Jorgen Frokiær ) , ( Soren Nielsen )
발행기관
대한신장학회
간행물정보
Kidney Research and Clinical Practice(구 대한신장학회지) 2013년, 제32권 제3호, 96~102페이지(총7페이지)
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18608181.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    The kidneys play a key role in the homeostasis of body water and electrolyte balance. Aquaporin-2 (AQP2) is the vasopressin-regulated water-channel protein expressed at the connecting tubule and collecting duct, and plays a key role in urine concentration and body-water homeostasis through short-term and long-term regulation of collecting duct water permeability. The signaling transduction pathways resulting in the AQP2 trafficking to the apical plasma membrane of the collecting duct principal cells, including AQP2 phosphorylation, RhoA phosphorylation, actin depolymerization, and calcium mobilization, and the changes of AQP2 abundance in water-balance disorders have been extensively studied. Dysregulation of AQP2 has been shown to be importantly associated with a number of clinical conditions characterized by body-water balance disturbances, including hereditary nephrogenic diabetes insipidus (NDI), lithium-induced NDI, electrolytes disturbance, acute and chronic renal failure, ureteral obstruction, nephrotic syndrome, congestive heart failure, and hepatic cirrhosis. Recent studies exploiting omics technology further demonstrated the comprehensive vasopressin signaling pathways in the collecting ducts. Taken together, these studies elucidate the underlying molecular mechanisms of body-water homeostasis and provide the basis for the treatment of bodywater balance disorders.
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