Case Report : Two cases of idiopathic membranous nephropathy treated with rituximab

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( Jae Young Yoon ) , ( Seung Tae Han ) , ( Ajin Cho ) , ( Hye Ryoun Jang ) , ( Jung Eun Lee ) , ( Woo Seong Huh ) , ( Dae Joong Kim ) , ( Ha Young Oh ) , ( Yoon Goo Kim )
Kidney Research and Clinical Practice(구 대한신장학회지) 2013년, 제32권 제3호, 138~141페이지(총4페이지)
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    Idiopathic membranous nephropathy is a common cause of nephrotic syndrome, and has been reported as a cause of idiopathic primary glomerulonephropathy in up to 90% of patients. However, the treatment options remain controversial. We report two cases of idiopathic membranous nephropathy that were treated with rituximab. A 54-yearold man and a 64-year old man were admitted for rituximab therapy. They had previously been treated with combinations of immunosuppressive agents including cyclophosphamide, cyclosporine, mycophenolate, and steroids. However, the patients` heavy proteinuria was not resolved. Both patients received rituximab therapy, 2 weeks apart. After several months of follow-up and a second round of rituximab treatment for each patient, their proteinuria decreased and partial remission of disease was achieved in both patients.
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