실크 피브로인을 함유한 비출혈용 복합 지혈제 개발에 대한 연구
분야
의약학 > 의공학
저자
문보미 ( Bo Mi Moon ) , 주형우 ( Hyung Woo Ju ) , 박현정 ( Hyun Jung Park ) , 이정민 ( Jung Min Lee ) , 이옥주 ( Ok Joo Lee ) , 박찬흠 ( Chan Hum Park )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2013년, 제10권 41~47페이지(총7페이지)
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2a800642.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Epistaxis is defined as active bleeding arising from the nasal mucosa. It constitutes one of the most common otolaryngology emergencies and can be severe or even fatal. Hemostasis is a process which causes bleeding to stop, meaning to keep blood within a damaged blood vessel which involves differential sequential events. This system in humans has been the most extensively researched. However, lot of research work is going on and lot more needs to be done to overcome the problem associated with this serious issue. This study was conducted to develop a new sponge type of biomaterial to be used for ideal hemostatic agent. The combination of three biomaterials; Silk fibroin (SF), Hyaluronic acid (HA), Gelatin (Gel) and Polyvinyl alcohol (PVA) as proposed hemostatic agent were tested against commercially available hemostatic pad (ChitoClot®). A comparative study of these silk based hemostasis agents designed in combination of SF/HA/PVA and SF/Gel/PVA sponges were tested on injured model of rats. Each sponge to be tested was made same size of (1×1 cm) then applied on top of injury site while applying a pressure of 5 N for 30 seconds. The In vivo experiments were carried by creating a proximal arterial injury in unilateral femoral arteries of 12 anesthetized SD rats. In conclusion, this study suggest a new developed silk fibroin-based sponges as hemostatic materials, which induced durable hemostasis and an increased blood clotting in animal studies. These initial studies explores the loopholes present in the existing ChitoClot® pad compared with that of fabricated silkbased sponges.
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