두개골 결손이 있는 가토에서 Polybone®, Tisseel®과 Eglandin®이 골형성에 미치는 영향
분야
의약학 > 의공학
저자
윤청민 ( Chung Min Yoon ) , 김명훈 ( Myung Hoon Kim ) , 김민수 ( Min Su Kim ) , 김석권 ( Seok Kwun Kim ) , 김수진 ( Su Jin Kim ) , 이근철 ( Keun Cheol Lee )
발행기관
한국조직공학·재생의학회
간행물정보
조직공학과 재생의학 2013년, 제10권 48~55페이지(총8페이지)
파일형식
2a800643.pdf [무료 PDF 뷰어 다운로드]
  • ※ 본 자료는 참고용 논문으로 수정 및 텍스트 복사가 되지 않습니다.
  • 구매가격
    4,500원
    적립금
    135원 (구매자료 3% 적립)
    이메일 발송  스크랩 하기
    자료 다운로드  네이버 로그인
    영문초록
    In plastic and reconstructive surgery, reconstruction of bone defect is commonly required in congenital anomaly or trauma. Autogenous bone graft is the most ideal material to reconstruct bone defect. Using the autogenous bone graft, however, is limited due to donor site morbidity and limitation of harvesting. β-tricalcium phosphate (β-TCP) is a homogenous high-purity chemical synthetic material with osteoconductivity. Fibrin forms the environment for fibroblast proliferation and accelerates wound healing. And Lipo-PGE1 promotes vasodilation and prevents platelet aggregation, and induces neovascularization. Thirty-two rabbits were divided 8 groups and 4 bone defects were made on each rabbit`s cranial bone. Bone defects were divided into four groups: control group, β-TCP group, fibrin sealant group, and β-TCP with fibrin sealant group. Lipo-PGE1 was intravenously injected to 16 rabbits, while normal saline was intravenously injected to the others. Results were evaluated by gross, histomorphological and histomorphometrical analysis at 1 week, 2 weeks, 4 weeks, 12 weeks after implantation. Mean percentage of the new bone formation area of β-TCP with fibrin sealant group was statistically significantly higher than that of the other groups. Although there was no statistical significance, mean percentage of the new bone formation area of applying Lipo-PGE1 group was higher than that of not applying Lipo-PGE1 group. We could verify the possibility of β-TCP with fibrin sealant being helpful in new bone formation. And we suggested the possibility of Lipo-PGE1 being helpful in new bone formation.
    사업자등록번호 220-87-87785 대표.신현웅 주소.서울시 서초구 방배로10길 18, 402호 대표전화.070-8809-9397
    개인정보책임자.박정아 통신판매업신고번호 제2017-서울서초-1765호 이메일 help@reportshop.co.kr
    copyright (c) 2009 happynlife. steel All reserved.