keyword we classify into medical effect paper. -A)Lonicera Japonica effect. B) chemical components of Lonicera Japonica. Results: Obtained in this study that active compounds or Lonicera Japanica are tannin, lonicerin, ochnaflavone. flavol1oids: chlorogenic acid. Quercetin, luteolin, saponins: loniceroside A. The first, medicinal effect of crude extract of Lonicera Japonica were anti-aging effect, anti-inflammation effect, anti-cancer effect, antibacterial effect, effect of the heavy metals detoxiJicarion, protective efr:ect liver. intestinal mucosa and Reflux Esophagitis. The second, the reported that flavoniods: luteolin, quercetin have anti-aging effect, anti-inflammation effect, chlorogenic acid have antilipidperoxidative effect. inhibition of cholesterol biosynthesis, anti-aging effect and anti-cancer effect. tannin have antibacterial effect, antiviral effect, ochnaflavone have effect of growth hormone-secreting. Conclusion: These component suggest that Lonicera Japonica may be used in the clinical field against several disease, such as anti-aging, anti-inflammation, anti-cancer, antibacterial effect, heavy metals detoxification. protective of liver, intestinal mucosa and Reflux Esophagitis. This research is shown that relation between pharmacological action of chemical component and effects of oriental medicine. Furthermore, research is need.