Previous research reported that body size measured as Body Mass Index (BMI) and body shape measured as waist-hip-ratio (WHR) are two essential factors that form the perceptions of body attractiveness. However, the debate on the importance of BMI versus WHR is ongoing. In addition, scholarly articles, that focus on the role of geographic and cultural variability on perceptions of attractiveness, report inconsistent results. Some suggested that according to globalization and the rise of mass media, geographic variability of perceptions of attractiveness have been altered, while others believed that it remains. This study cross-regionally investigates the role of body size and body shape on the perceptions of female attractiveness. Samples were composed of 107 female college students in Alabama and 107 female college students in California. Participants viewed 27 three-dimensional body scan images of women in three body shapes (pear, hourglass, and rectangle) and three body sizes (underweight, normal weight, and overweight) and rated their perceptions of attractiveness. Images were shown to students in a random order with an overhead projector and Microsoft Office PowerPoint software. A three-way mixed-ANOVA was conducted to analyze the data. The results of the study showed that some regional differences exist between the two sample groups. However, regardless of the regional difference, hourglass shapes were perceived to be the most attractive shape and underweight sizes were perceived to be the most attractive size for both samples.