REVIEW : Biomedical Application of Phosphoproteomics in Neurodegenerative Diseases
분야
자연과학 > 생물
저자
( Young Yil Bahk ) , ( Bari Mohamed ) , ( Young Jun Kim )
발행기관
한국미생물생명공학회(구 한국산업미생물학회)
간행물정보
Journal of Microbiology and Biotechnology 2013년, 제23권 제3호, 279~288페이지(총10페이지)
파일형식
05212219.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Phosphorylation and dephosphorylation of proteins trigger many critical events involved in cellular response, such as regulation of enzymatic activity, protein conformational change, protein-protein interaction, and cellular localization. Any malfunction of protein phosphorylation leads to a diseased state such as diabetes, cancer, and even neurodegenerative diseases. In order to comprehend the molecular view of the complex biological processes of these diseases in depth, very sensitive and detailed analytical methods are necessary for identification of the phosphorylated residues in a protein. As part of these efforts, phosphoproteomics has been developed and applied for the elucidation of neurodegenerative diseases. In this review, we present a brief summary of phosphoproteomics approaches that are now routinely used in biomedical research, and describe the biomedical application of phosphoproteomics especially in Alzheimer`s and other neurodegenerative diseases.
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