Glyceraldehyde-3-Phosphate Dehydrogenase, an Immunogenic Streptococcus equi ssp. zooepidemicus Adhesion Protein and Protective Antigen

분야
자연과학 > 생물
저자
( Qiang Fu ) , ( Zi Gong Wei ) , ( Xiao Hong Liu ) , ( Ping Ping Xiao ) , ( Zhao Hui Lu ) , ( Yao Sheng Chen )
발행기관
한국미생물생명공학회(구 한국산업미생물학회)
간행물정보
Journal of Microbiology and Biotechnology 2013년, 제23권 제4호, 579~585페이지(총7페이지)
파일형식
05212258.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Streptococcus equi ssp. zooepidemicus (Streptococcus zooepidemicus, SEZ) is an important pathogen associated with opportunistic infections of a wide range of species, including pigs and humans. The absence of a suitable vaccine makes it difficult to control SEZ infection. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has been previously identified as an immunogenic protein using immunoproteomic techniques. In the present study, we confirmed that the sequence of GAPDH was highly conserved with other Streptococcus spp. The purified recombinant GAPDH could elicit a significant humoral antibody response in mice and confer significant protection against challenge with a lethal dose of SEZ. GAPDH could adhere to the Hep-2 cells, confirmed by flow cytometry, and inhibit adherence of SEZ to Hep-2 cells in an adherence inhibition assay. In addition, real-time PCR demonstrated that GAPDH was induced in vivo following infection of mice with SEZ. These suggest that GAPDH could play an important role in the pathogenesis of SEZ infection and could be a target for vaccination against SEZ.
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