Cinvited Review : Targeting the Transforming Growth Factor-β Signaling in Cancer Therapy
분야
의약학 > 약화학
저자
( Yhun Yhong Sheen ) , ( Min Jin Kim ) , ( Sang A Park ) , ( So Yeon Park ) , ( Jeong Seok Nam )
발행기관
한국응용약물학회
간행물정보
Biomolecules & Therapeutics(구 응용약물학회지) 2013년, 제21권 제5호, 323~331페이지(총9페이지)
파일형식
53902388.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    TGF-β pathway is being extensively evaluated as a potential therapeutic target. The transforming growth factor-β (TGF-β) signaling pathway has the dual role in both tumor suppression and tumor promotion. To design cancer therapeutics successfully, it is important to understand TGF-β related functional contexts. This review discusses the molecular mechanism of the TGF-β pathway and describes the different ways of tumor suppression and promotion by TGF-β. In the last part of the review, the data on targeting TGF-β pathway for cancer treatment is assessed. The TGF-β inhibitors in pre-clinical studies, and Phase I and II clinical trials are updated.
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