Original Article : Ethacrynic Acid Inhibits Sphingosylphosphorylcholine-Induced Keratin 8 Phosphorylation and Reorganization via Transglutaminase-2 Inhibition
분야
의약학 > 약화학
저자
( Hyun Jung Byun ) , ( Kyung Jin Kang ) , ( Mi Kyung Park ) , ( Hye Ja Lee ) , ( June Hee Kang ) , ( Eun Ji Lee ) , ( You Ri Kim ) , ( Hyun Ji Kim ) , ( Young Woo Kim ) , ( Kyung Chae Jung ) , ( Soo Youl Kim ) , ( Chang Hoon Lee )
발행기관
한국응용약물학회
간행물정보
Biomolecules & Therapeutics(구 응용약물학회지) 2013년, 제21권 제5호, 338~342페이지(총5페이지)
파일형식
53902390.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Sphingosylphosphorylcholine (SPC) is signifi cantly increased in the malicious ascites of tumor patients and induces perinuclear reorganization of keratin 8 (K8) fi laments in PANC-1 cells. The reorganization contributes to the viscoelasticity of metastatic cancer cells resulting in increased migration. Recently, we reported that transglutaminase-2 (Tgase-2) is involved in SPC-induced K8 phosphorylation and reorganization. However, effects of Tgase-2 inhibitors on SPC-induced K8 phosphorylation and reorganization were not clearly studied. We found that ethacrynic acid (ECA) concentration-dependently inhibited Tgase-2. Therefore, we examined the effects of ECA on SPC-induced K8 phosphorylation and reorganization. ECA concentration-dependently suppressed the SPC-induced phosphorylation and perinuclear reorganization of K8. ECA also suppressed the SPC-induced migration and invasion. SPC induced JNK activation through Tgase-2 expression and ECA suppressed the activation and expression of JNK in PANC-1 cells. These results suggested that ECA might be useful to control Tgase-2 dependent metastasis of cancer cells such as pancreatic cancer and lung cancers.
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