Original Article : Hesperidin Suppresses Melanosome Transport by Blocking the Interaction of Rab27A-Melanophilin
분야
의약학 > 약화학
저자
( Bora Kim ) , ( Jee Young Lee ) , ( Ha Yeon Lee ) , ( Ky Youb Nam ) , ( Jong Il Park ) , ( Su Min Lee ) , ( Jin Eun Kim ) , ( Joo Dong Lee ) , ( Jae Sung Hwang )
발행기관
한국응용약물학회
간행물정보
Biomolecules & Therapeutics(구 응용약물학회지) 2013년, 제21권 제5호, 343~348페이지(총6페이지)
파일형식
53902391.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    We investigated the inhibitory effects of hesperidin on melanogenesis. To fi nd melanosome transport inhibitor from natural products, we collected the structural information of natural products from Korea Food and Drug Administration (KFDA) and performed pharmacophore-based in silico screening for Rab27A and melanophilin (MLPH). Hesperidin did not inhibit melanin production in B16F10 murine melanoma cells stimulated with α-melanocyte stimulating hormone (α-MSH), and also did not affect the catalytic activity of tyrosinase. But, hesperidin inhibited melanosome transport in melanocyte and showed skin lightening effect in pigmented reconstructed epidermis model. Therefore, we suggest that hesperidin is a useful inhibitor of melanosome transport and it might be applied to whitening agent.
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