Original Article : Anticolitic Effect of the Rhizome Mixture of Anemarrhena asphodeloides and Coptidis chinensis (AC-mix) in Mice
분야
의약학 > 약화학
저자
( Se Eun Jang ) , ( Jin Ju Jeong ) , ( Supriya R Hyam ) , ( Myung Joo Han ) , ( Dong Hyun Kim )
발행기관
한국응용약물학회
간행물정보
Biomolecules & Therapeutics(구 응용약물학회지) 2013년, 제21권 제5호, 398~404페이지(총7페이지)
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53902398.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    During a screening program to search the anticolitic herbal medicines, 80% ethanol extract of the rhizome of Anemarrhena asphodeloides (AA) was found to potently inhibit the expression of proinfl ammatory cytokines TNF-α and IL-1β, as well as the activation of NF-κB in LPS-stimulated colonic macrophages, followed by that of the rhizome of C. chinensis (CC). AA also potently inhibited TNBS-induced colitic markers, shortening of the colon and increase of macroscopic score, myeloperoxidase activity, TNF-α, IL-1β, and IL-6, in mice. The synergistic effect of CC against the anticolitic effect of AA was investigated. CC synergistically inhibited the anticolitic effect of AA. AC-mix (AA+CC, 1:1) potently inhibited them. AC-mix also inhibited the activation of NF-κB, as well as the expression of TNF-α, IL-1β, IL-6, iNOS and COX-2. The effects of AC-mix against oxazolone-induced colitis were investigated in mice. AC-mix also potently inhibited oxazolone-induced infl ammatory markers, colon shortening, macroscopic score, myeloperoxidase activity, NF-κB activation and proinfl ammatory cytokines. Overall, the anti-colitic effect of AC-mix was superior to that of mesalazine. Based on these fi ndings, AC-mix may improve colitis by inhibiting NF-κB activation.
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