Orientia tsutsugamushi Infection Induces CD4+ T Cell Activation via Human Dendritic Cell Activity
분야
자연과학 > 생물
저자
( Hyuk Chu ) , ( Sung Moo Park ) , ( In Su Cheon ) , ( Mi Yeoun Park ) , ( Byoung Shik Shim ) , ( Byoung Cheol Gil ) , ( Woon Hee Jeung2 ) , ( Kyu Jam Hwang ) , ( Ki Duk Song ) , ( Kee Jong Hong ) , ( Manki Song ) , ( Hang Jin Jeong ) , ( Seung Hyun Han )
발행기관
한국미생물생명공학회(구 한국산업미생물학회)
간행물정보
Journal of Microbiology and Biotechnology 2013년, 제23권 제8호, 1159~1166페이지(총8페이지)
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05212337.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Orientia tsutsugamushi, a gram-negative bacterium, causes severe acute febrile illness in humans. Despite this danger, the route of infection, infectivity, and protective mechanisms of the host``s immune response to O. tsutsugamushi are unclear. Dendritic cells (DCs) are one of the most important cell types in bridging the innate and adaptive immune responses. In this study, we observed that O. tsutsugamushi infects and replicates in monocyte-derived DCs (MODCs). During infection and replication, the expressions of the cytokines IL-12 and TNF-α, as well as the co-stimulatory molecules CD80, CD83, CD86, and CD40, were increased in MODCs. When O. tsutsugamushi-treated MODCs were co-cultured with autologous CD4+ T cells, they enhanced production of IFN-γ, a major Th1 cytokine. Collectively, our results show that O. tsutsugamushi can replicate in MODCs and can simultaneously induce MODC maturation and increase proinflammatory cytokine levels in MODCs that subsequently activate CD4+ T cells.
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