Analysis of Transcriptional Profiles to Discover Biomarker Candidates in Mycobacterium avium subsp. paratuberculosis-Infected Macrophages, RAW 264.7
자연과학 > 생물
( Seung Bin Cha ) , ( Anna Yoo ) , ( Hong Tae Park ) , ( Kyoung Yong Sung ) , ( Min Kyoung Shin ) , ( Han Sang Yoo )
한국미생물생명공학회(구 한국산업미생물학회)
Journal of Microbiology and Biotechnology 2013년, 제23권 제8호, 1167~1175페이지(총9페이지)
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    Paratuberculosis (PTB) or Johne``s disease is one of the most serious chronic debilitating diseases of ruminants worldwide that is caused by Mycobacterium avium subsp. paratuberculosis (MAP). MAP is a slow-growing bacterium that has very long latent periods, resulting in difficulties in diagnosing and controlling the disease, especially regarding the diagnosis of fecal shedders of MAP without any clinical signs. Based on this situation, attempts were made to identify biomarkers that show early responses to MAP infection in a macrophage cell line, RAW 264.7. In response to the infection with the bacterium, a lot of genes were turned on and/or off in the cells. Of the altered genes, three different categories were identified based on the time-dependent gene expression patterns. Those genes were considered as possible candidates for biomarkers of MAP infection after confirmation by quantitative RT-PCR analysis. To the best of our knowledge, this is the first attempt at discovering the host transcriptomic biomarkers of PTB, although further investigation will be required to determine whether these biomarker candidates are associated within the natural host.
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