Objectives: The hiccup sign is a common symptom associated with acute medulla infarction. We have a case report of the patient who has a continuous and serious hiccup sign. Methods: In this study the patient cured by herbal medication. Other treatments were acupuncture, moxibustion for 15 days. Results and Conclusions: In the result, the serious hiccup sign continued for 10 days. The symptom was improved and disappeared in 11-15 days. So we report the healing process and result of this patient in this study.