|Background: Globus is a persistent or intermittent non-painful sensation of a lump or foreign body in the throat and commonly encountered clinical condition. We aim to evaluate the prevalence of Gastro-esophageal refl ux disease (GERD) and to determine the parameter of predicting the response to treatment with proton pump inhibitor using wireless pH monitoring in patients with globus sense. Methods: We retrospectively reviewed the medical records of 37 patients with atypical GERD symptoms. A total 27 patients with dominant globus sense was enrolled. Endoscopic examination and 48-hour wireless esophageal pH monitoring were executed, and they underwent a therapeutic trial of full dose PPIs daily over 4 weeks. Results: In 14 patients (51.9%, 14/ 27), both typical and atypical GERD symptoms were co-existed. According to ROME III criteria, 19 patients (70%, 19/ 27) were diagnosed as GERD. Twelve patients (44%, 12/27) were PPI responder. There was a signifi cant difference in the frequency of symptom index (+) or symptom associated probability (+) between the PPI responder and non- responder (P<0.01). Conclusions: In patients with globus sense, 70% of them were diagnosed with GERD. Symptom index/symptom associated probability in the wireless ambulatory pH monitoring was good objective parameters for PPI responder.