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The influence of number of high risk factors on clinical outcomes in patients with early-stage cervical cancer after radical hysterectomy and adjuvant chemoradiation
분야 의약학 > 산부인과학
저자 ( So Yi Lim ) , ( Seok-ho Lee ) , ( Kwang Beom Lee ) , ( Chan-yong Park )
발행기관 대한산부인과학회
간행물정보 Obstetrics & Gynecology Science 2016년, 제59권 제3호, 184~191쪽(총8쪽)
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연관 논문
Case Reports : Successful twin pregnancy by assisted reproductive technology after Laparoscopic-assisted radical vaginal trachelectomy
GO-27 : Single-port nerve sparing laparoscopic radical hysterectomy with extended node dissection for cervical cancer
Treatment outcomes in patients with FIGO stage IB-IIA cervical cancer and a focally disrupted cervical stromal ring on magnetic resonance imaging: a propensity score matching study
Laparoendoscopic single site surgery for cervical cancer: A single surgeon experience
GO04 : Comparison of oncologic outcome between laparoscopic radical hysterectomy and abdominal radical hysterectomy stratified by risk factors and adjuvant radiotherapy in cervical cancer
 
 
영문초록
Objective The purpose of this study was to evaluate the prognosis according to the number of high risk factors in patients with high risk factors after radical hysterectomy and adjuvant chemoradiation therapy for early stage cervical cancer. Methods Clinicopathological variables and clinical outcomes of patients with FIGO (International Federation of Gynecology and Obstetrics) stage IB1 to IIA cervical cancer who had one or more high risk factors after radical hysterectomy and adjuvant chemoradiation therapy were retrospectively analyzed. Patients were divided into two groups according to the number of high risk factors (group 1, single high risk factor; group 2, two or more high risk factors). Results A total of 93 patients were enrolled in the present study. Forty nine out of 93 (52.7%) patients had a single high risk factor, and 44 (47.3%) had two or more high risk factors. Statistically significant differences in stage and stromal invasion were observed between group 1 and group 2. However, age, histology, tumor size, and lymphovascular space invasion did not differ significantly between the groups. Distant recurrence occurred more frequently in group 2, and the probability of recurrence and death was higher in group 2. Conclusion Patients with two or more high risk factors had worse prognosis in early stage cervical cancer. For these patients, consideration of new strategies to improve survival may be worthwhile. Conduct of further clinical trials is warranted for development of adjuvant treatment strategies individualized to each risk group.
 
 
Chemoradiation, High-risk factor, Prognosis, Radical hysterectomy, Uterine cervical neopla msm
 
 
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