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Effects of (-)-Sesamin on Memory Deficits in MPTP-lesioned Mouse Model of Parkinson`s Disease
분야 의약학 > 약화학
저자 ( Ting Ting Zhao ) , ( Keon Sung Shin ) , ( Myung Koo Lee )
발행기관 한국생약학회
간행물정보 Natural Product Sciences 2016년, 제22권 제4호, 246~251쪽(총6쪽)
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This study investigated the effects of (-)-sesamin on memory deficits in 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-lesioned mouse model of Parkinson`s disease (PD). MPTP lesion (30 mg/kg/day, 5 days) in mice showed memory deficits including habit learning memory and spatial memory. However, treatment with (-)-sesamin (25 and 50 mg/kg) for 21 days ameliorated memory deficits in MPTP-lesioned mouse model of PD: (-)-sesamin at both doses improved decreases in the retention latency time of the passive avoidance test and the levels of dopamine, norepinephrine, 3,4-dihydroxyphenylacetic acid, and homovanillic acid, improved the decreased transfer latency time of the elevated plus-maze test, reduced the increased expression of N-methyl-Daspartate (NMDA) receptor, and increased the reduced phosphorylation of extracellular signal-regulated kinase (ERK1/2) and cyclic AMP-response element binding protein (CREB). These results suggest that (-)-sesamin has protective effects on both habit learning memory and spatial memory deficits via the dopaminergic neurons and NMDA receptor-ERK1/2-CREB system in MPTP-lesioned mouse model of PD, respectively. Therefore, (-)- sesamin may serve as an adjuvant phytonutrient for memory deficits in PD patients.
(-)-Sesamin, MPTP-lesioned mouse model of Parkinson`s disease, Habit learning memory, Spatial memory, Dopaminergic neuron, NMDA receptor
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