Exfoliative cheilitis is a rare and chronic inflammatory condition affecting the vermilion of the lips and characterized by continuous peeling of the vermilion and production of a thick keratin scale. Conventional topical treatment of exfoliative cheilitis such as keratolytic lip balms, sunscreen, antifungal creams and topical steroids is helpful in some cases but it is not that effective in most cases. Conventional invasive treatment such as peeling with laser, cryosurgery and electrocautery is effective in some cases but it causes severe pain, discomforts, scarring and delayed wound healing. . In our case, a 42-year-old man was referred because of chronic thick hyperkeratotic plaques on both lips. It was resistant to conventional treatments. We treated him with pinhole method using Co2 laser. The lesion of the patient was almost improved without side effect and treatment effects lasted three to four months. This treatment was more effective with minimal side effects than conventional treatments. Clinicians should keep this treatment in mind while dealing with patients with treatment-resistant and chronic exfoliative cheilitis.