Systemic White Blood Cell Count as a Biomarker Associated with Severity of Chronic Obstructive Lung Disease
분야
의약학 > 내과학
저자
( Hyeon-kyoung Koo ) , ( Hyung Koo Kang ) , ( Pamela Song ) , ( Hye Kyeong Park ) , ( Sung-soon Lee ) , ( Hoon Jung )
발행기관
대한결핵 및 호흡기학회
간행물정보
Tuberculosis and Respiratory Diseases 2017년, 제80권 제3호, 304~312쪽(총9쪽)
파일형식
0y911661.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Background: Chronic obstructive pulmonary disease (COPD), is a chronic inflammatory disorder. We evaluated whether white blood cell (WBC) count, is associated with the severity of COPD, independent of other inflammatory conditions, such as metabolic syndrome. Methods: The WBC counts were compared between 1227 COPD patients and 8679 non-COPD adults older than 40. The relationships between the WBC count, lung function, and symptoms score in COPD patients, were determined, using general linear regression analyses. Results: The WBC count was negatively associated with forced vital capacity (FVC, L), FVC (% predicted), forced expiry volume in one second (FEV1, L), and FEV1 (% predicted) in COPD patients. Additionally, the WBC count was independently associated with the quality of life measure, by EQ5D-index score. However, this relationship between WBC count, and disease severity, was not significant in current smokers, because of the confounding effect of smoking, on the WBC count. Conclusion: The WBC count is associated with current smoking status and COPD severity, and a risk factor for poor lung function, and quality of life, especially in non-currently smoking COPD patients. The WBC count can be used, as an easily measurable COPD biomarker.
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