패장(敗醬) 물 추출물의 LPS로 유도된 RAW 264.7 세포와 mouse 염증모델에서 cytokine 및 NF-κB의 활성에 미치는 효과
분야
의약학 > 기초한의학
저자
류익한 ( Ik-han Ryu ) , 조해중 ( Hae-joong Cho ) , 송미화 ( Mi-hwa Song ) , 최창민 ( Chang-min Choi )
발행기관
대한한방부인과학회
간행물정보
대한한방부인과학회지 2017년, 제30권 제2호, 1~15페이지(총15페이지)
파일형식
35901118.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Objectives: The object of this study was to identify the anti-inflammatory effects of Patrinia scabiosaefolia aqueous extract (PSE).
    Methods: RAW 264.7 cells were pre-treated with PSE and then incubated with or without lipopolysaccharide (LPS). Cell viability, production of nitric oxide (NO), secretion of pro-inflammatory cytokine, activation of mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-κB) were measured. In addition, we observed mice survival rate after LPS and their cytokine levels of serum. We also observed inflammatory and hemorrhagic change on the histological sections of the liver.
    Results: PSE inhibited LPS-induced NO production, interleukin (IL)-6 secretion, c-Jun NH2-terminal kinase (JNK) and NF-κB activation. In addition, PSE reduced the death rate of LPS-induced mice and IL-6 production on the serum of mice. PSE inhibited inflammation and hemorrhage on liver tissue as well.
    Conclusions: The results suggest that PSE have anti-inflammatory effects by inhibited NF-κB and JNK activation, IL-6 secretion, and NO production. So PSE may be effective treatment for the inflammatory disease.
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