Objectives: Artemisiae Annuae Herba is the dried aerial part of Artemisia annua L. (AAL). In Oriental medicine, Artemisiae Annuae Herba (AAH) is traditionally used to treat fever. AAH clears summerheat or damp-Heat, clears deficiency fevers, cools the blood and stops bleeding, stops malarial disorders and relieves heat, clears liver heat and brightens the eyes. Recently, there were many studies about effects of AAH on anti-oxidative, anti-inflammatory, anti-cancer, hair growth and plasma lipid composition. So, we expected AAH has an availability that can effect on skin whitening and elasticity.
Methods: The present study was designed to investigate the effects of AAH on skin whitening and elasticity in SK-MEL-2 cells. In this experiment, the effects of AAH on proliferation rates, melanin synthesis, tyrosinase activities and production levels of tyrosinase, MMP-1 and MMP-9 in vitro were examined.
Results: AAH did not affect viability of SK-MEL-2 cells and inhibited melanin synthesis induced by α-Melanocyte-stimulating hormone (α-MSH) significantly. In addition, AAH also inhibited tyrosinase activity and lowered tyrosinase level in SK-MEL-2 cells. Finally, AAH inhibited productions of Matrix metalloproteinase-1 (MMP-1) and Matrix metalloproteinase-9 (MMP-9).
Conclusions: These data suggest that AAH can be used to treat patients with skin diseases such as freckled face and also used as skin whitening agent.
[활성산소, SOD] 활성산소의 정의와 활성산소의 발생원인, 활성산소의 생성요인 및 활성산소를 치료하는 SOD에 관한 심층 분석
비트코인 정의와 미래전망연구 PPT- 비트코인 정의,특징,생성원리,거래방법분석및 비트코인 위기와 논란분석및 거래활성화 방안제언과 미래전망연구
[생물소재공학] 새로운 미백 소재 ‘강황’ 제품개발 기획
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[생약학] 주름개선 한방 화장품 개발 보고서
미백 기능성 화장품 제품 분석
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[식품영양] 천연식품 추출물에서의 골다공증예방기전