응급진료센터에 내원한 ST 분절 상승 심근 경색 환자에서 혈소판 용적 지표의 연속 측정을 통한 30일 사망률 예측의 유용성
분야
의약학 > 외과학
저자
유지나 ( Gina Yu ) , 유제성 ( Je Sung You ) , 정성필 ( Sung Phil Chung ) , 공태영 ( Taeyoung Kong ) , 고동률 ( Dongryul Ko ) , 김시내 ( Sinae Kim ) , 주영선 ( Youngseon Joo ) , 황윤정 ( Yoon Jung Hwang ) , 좌민홍 ( Minhong Choa ) , 박인철 ( Incheol Park )
발행기관
대한응급의학회
간행물정보
대한응급의학회지 2017년, 제28권 제5호, 514~525페이지(총12페이지)
파일형식
18404585.pdf [무료 PDF 뷰어 다운로드]
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    영문초록
    Purpose: Among the survivors of a ST elevation myocardial infarction (STEMI), higher platelet volume indices (mean platelet volume, MPV; platelet distribution width, PDW) are associated with impaired reperfusion and ventricular dysfunction. This study examined the relationship between the platelet volume indices and 30-day mortality with STEMI patients who underwent primary percutaneous coronary intervention (PCI).
    Methods: This retrospective cohort study included patients presenting to the emergency department with STEMI between January 2011 and May 2016. The platelet volume indices were measured serially, using an automatic hematology analyzer, from admission to 24 hours after admission. The prognostic value of MPV, PDW for the 30-day mortality was determined by Cox proportional hazards model analysis.
    Results: A total of 608 STEMI patients, who underwent reperfusion, were enrolled in this study. According to the multivariable Cox proportional hazard model, higher MPV (hazard ratio [HR], 1.414; 95% confidence interval [CI], 1.024-1.953; p=0.035) and PDW (HR, 1.043; 95% CI, 1.006-1.083; p=0.024) values at time-24 (24 hours after admission) were significant risk factors for the 30-day mortality. A MPV value >8.6 fL (HR, 5.953; 95% CI, 2.973-11.918; p< 0.001) and PDW value >56.1% (HR, 5.117; 95% CI, 2.640-9.918; p<0.001) at time-24 were associated with an increased risk of 30-day mortality.
    Conclusion: The platelet volume indices without an additional burden of cost or time, can be measured rapidly and simply. Higher MPV and PDW levels predict independently the 30-day mortality in patients with STEMI after PCI.
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