|Hydrogen production from methanol partial oxidation is experimentally investigated in this study. Three different catalysts, including Pt/Al2O3, h-BN-Pt/Al2O3, and h-BN-Pd/Al2O3, are used to aid in the chemical reaction, and methanol is sent into the catalyst bed in the form of sprays. The partial oxidation is autothermally triggered when the first two catalysts are individually used. Meanwhile, the second and third catalysts are combined together to triggered the chemical reaction. The influences of the O2-to-methanol molar ratio (the O2/C ratio) and the types of catalysts on the partial oxidation are explored. The gaseous concentrations in the product gas, reaction temperature, and hydrogen yields under various operating conditions are examined. In addition, the thermodynamic analysis is also performed to evaluate the performance of the chemical reaction. The details of the results will be demonstrated and discussed.