Seismic isolation systems have typically been used in the form of base seams in mid-rise and low-rise buildings. In the case of high-rise buildings, it is difficult to apply the base isolation. In this study, the seismic response was analyzed by changing the installation position of the seismic isolation device in 3D high - rise model. To do this, we used 30-story and 40-story 3D buildings as example structures. Historic earthquakes such as Mexico (1985), Northridge (1994) and Rome Frieta (1989) were applied as earthquake loads. The installation position of the isolation device was changed from floor to floor to floor. The maximum deformation of the seismic isolation system was analyzed and the maximum interlaminar strain and maximum absolute acceleration were analyzed by comparing the LB model with seismic isolation device and the Fixed model, which is the base model without seismic isolation device. If an isolation device is installed on the lower layer, it is most effective in response reduction, but since the structure may become unstable, it is effective to apply it to an effective high-level part. Therefore, engineers must consider both structural efficiency and safety when designing a mid-level isolation system for high-rise buildings.