Background: Acne is a chronic skin disorder, and its inflammatory lesions leave scars which greatly affects the quality of life of patients. Currently, treatment options targeting both acne and acne scars are still lacking.
Objectives: To evaluate clinical efficacy of topical epidermal growth factor ointment (EGFO) on acne lesions and scars.
Methods: The study design was 12-week, prospective, split-face, non-blind. The 36 adult patients with mild to moderate acne vulgaris applied EGFO on one side of the face and vehicle ointment on the other side twice daily. Patients were assessed every 4 weeks by acne lesion and scar counts, investigator’s global assessment for acne (IGA) and scar (SGA), and ECCA scar grading scale. Skin biopsies were performed before and after treatment.
Results: The severity of acne and acne scars were significantly improved in EGFO-treated sides, while control sides were not. Acne lesion and scar counts were significantly reduced after 4 weeks, while IGA, SGA, and ECCA grades significantly decreased after 8 weeks. Immunohistochemistry showed decreased expression of keratin 16, NFkBp65, IL-1α in acne lesions, and increased expression of elastin, collagen type 1, 3 in acne scars after treatment.
Conclusion: EGFO can be a treatment option for acne and acne scar.