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분야 : 의약학 > 약화학
발행기관 : 한국응용약물학회
간행물정보 : Biomolecules & Therapeutics(구 응용약물학회지), 2012 pp.487~491 (총 5pages)
 
 
영문초록
The aim of this study was to investigate the inhibitory effects of rutaecarpine on DNA strand breaks and apoptosis induced by hydrogen peroxide (H2O2) in murine Hepa-1c1c7 cells. Oxidative DNA damage was estimated by nuclear condensation assessment, fluorescence-activated cell sorting analysis, and Comet assay. Rutaecarpine inhibited cell death induced by 500 mM H2O2, as assessed by 4`,6-diamidino-2-phenylindole (DAPI) staining. Treatment with rutaecarpine reduced the number of DNA strand breaks induced by H2O2, as assessed by DAPI staining and Comet assay, and increased quinone reductase, phosphatidylinositol 3-kinase, and pAkt protein levels, as assessed by western blotting.
 
 
Rutaecarpine, Oxidative stress, DNA damage, Quinone reductase, Apoptosis, Hydrogen peroxi
 
다운로드 53902304.pdf