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분야 : 자연과학 > 화학
발행기관 : 생화학분자생물학회(구 한국생화학분자생물학회)
간행물정보 : BMB Reports, 2016 pp.~7 (총 8pages)
 
 
영문초록
The disease known as cerebral cavernous malformations mostly occurs in the central nervous system, and their typical histological presentations are multiple lumen formation and vascular leakage at the brain capillary level, resulting in disruption of the blood-brain barrier. These abnormalities result in severe neurological symptoms such as seizures, focal neurological deficits and hemorrhagic strokes. CCM research has identified ``loss of function`` mutations of three ccm genes responsible for the disease and also complex regulation of multiple signaling pathways including the WNT/β-catenin pathway, TGF-β and Notch signaling by the ccm genes. Although CCM research is a relatively new and small scientific field, as CCM research has the potential to regulate systemic blood vessel permeability and angiogenesis including that of the blood-brain barrier, this field is growing rapidly. In this review, I will provide a brief overview of CCM pathogenesis and function of ccm genes based on recent progress in CCM research. [BMB Reports 2016; 49(5): 255-262]
 
 
Angiogenesis, Central nervous system, Cerebral cavernous malformation, Signaling, Vascular permeability
 
다운로드 02618771.pdf