의대 본과 4학년 PK과제 Hypersensitivityreactions to Nonsteroidal AntiInflammatory Drug s

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본문내용
Hypersensitivity Reactions to Nonsteroidal Anti-Inflammatory
Drugs
The terms
‘‘Drug hypersensitivity’’
Symptoms or signs initiated by an exposure to a drug at a dose normally tolerated by nonhypersensitive persons
‘‘Drug allergy’’
immunologically mediated drug hypersensitivity reactions, which may be either Immunoglobulin E (IgE) mediated(immediate) or non-IgE-mediated (delayed)
‘‘Nonallergic hypersensitivity reactions’’
Adverse drug reactions that are not mediated by immunologic mechanisms
Nonsteroidal anti-inflammatory drugs (NSAIDs)
A group of substances of variable chemical composition that antagonize inflammation by interfering with the function of cyclooxygenases (COXs)
COXs are enzymes that participate in the conversion of arachidonic acid (AA) into prostaglandins (PGs) and thromboxanes, which are strong mediators of the inflammatory process
This inhibition results in the shunting of AA metabolism toward the 5-lipoxygenase pathway, resulting in the increased release of cysteinyl leukotrienes
There are 2 isoforms of COXs
COX-1 is the constitutive form present in all cells, whereas the inducible isoenzyme COX-2 is expressed exclusively in inflammatory cells after stimulation by cytokines, growth factors, bacterial lipopolysaccharide, tumor promoters, and other factors
Acetylsalicylic acid (ASA), also known as aspirin, and the classic NSAIDs inhibit both isoforms of COX, the new, selective COX-2 inhibitors are devoid of COX-1 inhibition and therefore have less ability to decrease gastric PG E2 (PGE2), producing less gastric irritation and ulceration