분야
pptxEffects of vitamin E on stroke subtypes: meta-analysis of
randomised controlled trials
BMJ 2010;341:c5702
Introduction
Vitamin E - lipid soluble antioxidant
inhibit lipid peroxidation by scavenging reactive oxygen species
Cardiovascular disease - atherogenesis
Key role : lipid peroxidation
randomised, placebo controlled trials of vitamin E on incident stroke and stroke subtypes
Methods
Data sources and searches
Two investigators search
Medline, Embase (from inception to January 2010) as well as the Cochrane Central Register of Controlled Trials, combining text terms and MeSH terms for vitamin E and stroke
limited search
humans, clinical trials, randomised controlled trials, meta-analyses, and systematic reviews
Methods
Study selection
Randomised, placebo controlled design with a follow-up of ≥1 year
Investigating the effect of vitamin E on stroke incidence
do not include trials of multivitamins or fixed vitamin combinations
