![[독성학] Atopic dermatitis-1](http://images.happyhaksul.com/thumb/391/390961-0001.gif)
![[독성학] Atopic dermatitis-2](http://images.happyhaksul.com/thumb/391/390961-0002.gif)
![[독성학] Atopic dermatitis-3](http://images.happyhaksul.com/thumb/391/390961-0003.gif)
![[독성학] Atopic dermatitis-4](http://images.happyhaksul.com/thumb/391/390961-0004.gif)
![[독성학] Atopic dermatitis-5](http://images.happyhaksul.com/thumb/391/390961-0005.gif)
![[독성학] Atopic dermatitis-6](http://images.happyhaksul.com/thumb/391/390961-0006.gif)
![[독성학] Atopic dermatitis-7](http://images.happyhaksul.com/thumb/391/390961-0007.gif)
![[독성학] Atopic dermatitis-8](http://images.happyhaksul.com/thumb/391/390961-0008.gif)
![[독성학] Atopic dermatitis-9](http://images.happyhaksul.com/thumb/391/390961-0009.gif)
![[독성학] Atopic dermatitis-10](http://images.happyhaksul.com/thumb/391/390961-0010.gif)
![[독성학] Atopic dermatitis-11](http://images.happyhaksul.com/thumb/391/390961-0011.gif)
![[독성학] Atopic dermatitis-12](http://images.happyhaksul.com/thumb/391/390961-0012.gif)
![[독성학] Atopic dermatitis-13](http://images.happyhaksul.com/thumb/391/390961-0013.gif)
![[독성학] Atopic dermatitis-14](http://images.happyhaksul.com/thumb/391/390961-0014.gif)
![[독성학] Atopic dermatitis-15](http://images.happyhaksul.com/thumb/391/390961-0015.gif)
![[독성학] Atopic dermatitis-16](http://images.happyhaksul.com/thumb/391/390961-0016.gif)
![[독성학] Atopic dermatitis-17](http://images.happyhaksul.com/thumb/391/390961-0017.gif)
![[독성학] Atopic dermatitis-18](http://images.happyhaksul.com/thumb/391/390961-0018.gif)
![[독성학] Atopic dermatitis-19](http://images.happyhaksul.com/thumb/391/390961-0019.gif)
![[독성학] Atopic dermatitis-20](http://images.happyhaksul.com/thumb/391/390961-0020.gif)
분야
ppt2.pruritogenic mediators
3.Histological alteration
4.Immunological abnormality
itch fiber
Histamine-sensitive
Low conduction velocity
Large innervation territories
Mechanical unresponsiveness
High electrical threshold
즉, itch fiber는
Histamine-positive mechano-insensitive
afferent C-fiber
diversity of cutaneous n.s.
Hypertrophy of nerve fiber
Enlarged axon
Axons lost their surrounding cytoplasm of Schwann cells.
Histological alteration(acute)
Intradermal vesicles
Spongiosis of epidermis
Dermal perivenular infiltration (lymphocyte, monocyte-macrophage)
Mast cell hypogranulation
Enlarged endothelial cells W/ large nuclei
