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분야
ppt2.History
3.Chemistry - Coenzyme Q10 Synthetic Pathway
4.Action Mechanism
5.Biochemistry - Function
6.Physiology - Clinical Effects(Disease), Precaution & Interaction, Bioavailability
7.Similar Molecules/Drugs
8.Summary
▪ Alternative names
- CoQ10 - Q10 - Vitamin Q10
- Ubiquinone - Ubidecarenone
▪ benzoquinone + isoprene
▪ 황색 또는 오렌지색의 결정상 퀴논 화합물.
▪ 지용성 물질로서 물에 거의 녹지 않는다.
▪ 코엔자임 Q6 ~10 등이 있으며 사람, 동물, 식물 등
에 존재하는데, 사람의 경우 대부분 코엔자임Q10.
▪ 냄새나 맛이 없다.
-생체내 semiquinone radical을 형성하여 미토콘드리아를 보호.
➾ 활성산소에 의한 세포 생체막의 구성성분인 불포화 지방산의 과산화 반응과 체내의 과산화 지질의 축적을 방해함으로써, 활성산소로 생겨나는 생체 기능 저하 및 성인병을 예방.
활성 산소가 과잉으로 계속 생성되면
몸의 지방질, 단백질, 당, 핵산 등이 산화되어 변성됨.
이처럼 세포가 변성되면서 세포막의 주된 재료 지방질이 산화되어
세포 자체의 기능이 저하됨.
우리 몸의 물질들이 산화되는 것을 "산화 스트레스"라고 함.
2. Crofts, A.R. (2004). The cytochrome bc1 complex: function in the context of structure. Annu Rev Physiol. 66, 689-733. PMID 14977419
3. Nicholls, David and Stuart Ferguson. Bioenergetics3. Acociate Press: San Diego, California 2002. pg 114-117
4. Skulachev, V. P. (1996) Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants. Q. Rev. Biophys. 29, 169-202
5. Muller, F. (2000) The Nature and Mechanism of Superoxide production by the Electron Transport Chain: Its relevance to aging. J. Amer. Aging Assoc. 23, 227-253
6. Muller, F. L., Liu, Y. and Van Remmen, H. (2004) Complex III Releases superoxide to both sides of the inner mitochondrial membrane. J. Biol. Chem. 279, 49064-49073
7. Han, D., Williams, E. and Cadenas, E. (2001) Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space. Biochem. J. 353, 411-416.
8. Muller, F. (2000) The Nature and Mechanism of Superoxide production by the Electron Transport Chain: Its relevance to aging. J. Amer. Aging Assoc. 23, 227-253
9. Muller, F. L., Liu, Y. and Van Remmen, H. (2004) Complex III Releases superoxide to both sides of the inner mitochondrial membrane. J. Biol. Chem. 279, 49064-49073
10. Enrique Teran, Isabel Hernandez, Belen Nieto, Rosio Tavara, Juan Emilio Ocampo, Andres Calle(2009) Coenzyme Q10 supplementation during pregnancy reduces the risk of pre-eclampsia. International Journal of Gynecology and Obstetrics 105 (2009) 43–45
http://www.coenzymeq10.co.kr/
http://en.wikipedia.org/wiki/Coenzyme_Q10
http://en.wikipedia.org/wiki/Complex_III
http://en.wikipedia.org/wiki/Vitamin_K
http://www.cancer.gov/cancertopics/pdq/cam/coenzymeQ10/Patient/page2
http://healthcare.daewoong.co.kr
http://cafe.naver.com/naturalvera88.cafe?iframe_url=/ArticleRead.nhn%3Farticleid=47
http://cafe.naver.com/ArticleRead.nhn?clubid=10050813&articleid=537105
http://www.blogsurf.co.kr/s/#228589/blog.naver.com/twinkiwis/150053480120/tag:코엔자임큐텐
http://kr.blog.yahoo.com/neolees/1138.html?p=1&t=3
http://www.coenzyme-q10.net/sideeffects.php
http://www.medicinenet.com/coenzyme_q10_ubiquinone_ubidecarenone-oral/article.htm
