소화기내분비 레포트
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목차
▦ General Characteristics of Hormones

▦ Localization of Gut Hormones
1.Hormones
2.Neuropeptides
3.Growth Factors & Cytokines

▦ Hormone Measurement

▦ Physiologic Action of Gut Hormones
1.Gastrin
2.Somatostatin
3.Cholecystokinin (CCK)
4.Secretin
5.Motilin
6.Gastric Inhibitory Polypeptide (GIP)
7.Pancreatic Polypeptide (PP)
8.Enteroglucagon
9.Neurotensin
10.Peptide YY (PYY)

▦ Physiology of Gut Neuropeptide
1.Endogenous Opioids
2.Substance P & Other Tachykinins
3.Vasoactive Intestinal Polypeptide (VIP)
4.Gastric Releasing Peptide (GRP) & Bombesin
5.Cholecystokinin (CCK)
6.Neuropeptide Y (NPY)
7.Calcitonin-Gene-Related Peptide (CGRP)
8.Galanin

▦ Hormones in Gastrointestinal Disease
1.Hormone Secreting Pancreatic Tumor - most common
2.Gastrin in Disease

▦ Neuropeptide in Disease
1.Achalasia
2.Eating Disorder

▦ Diagnostic Uses of GI Peptides
1.Pentagastrin Secretory Test
2.Secretin Pancreatic Secretory Testing
3.Secretin Provocative Testing for Gastrinoma - for DDx
4.Secretin in Pancreatic Radiology
5.CCK in Biliary Imaging
6.Glucagon in GI Radiology & Endoscopy

▦ Therapeutic Uses of GI Hormones
1.Somatostatin
2.Octreotide

▦ Endocrine Tumors of the GI Tract & Pan-creas
1.Carcinoid Tumor
2.Pancreatic Islet-cell Tumors
본문내용
▦ Physiologic Action of Gut Hormones
Criteria
① Peptide must be related into blood during time that a biologic response in a target organ is being stimulated or inhibited
② IV infusion of pure natural peptide must reproduce the effect on target organ
③ Synthetic peptide should reproduce the effect found with natural peptide
④ Circulating concentration of peptide that cause stimulation of target organ should be the same
⑤ The assay must not measure biologically inactive degradation product
⑥ It should be possible to prevent the physiologic response by removing the peptide from the blood or by specific antagonism at its receptor

1.Gastrin
Action
major hormonal stimulant of gastric acid secretion
trophic action to gastric mucosa
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