소개글
[의학과][성형외과] 성형외과 토픽 리뷰(Wound Healing)에 대한 자료입니다.
목차
1.Inflammatory phase
2.Proliferation phase
3.Remodeling phase
본문내용
Fibroplasia
Fibroblasts proliferate, they become the predominant cell type by 3 to 5 days in clean, noninfected wounds
Fibroblasts synthesize and secrete collagens
The major structural component of wound scar is collagen
In the ECM, tropocollagen is formed
laterally aggregate and covalently cross-linked by the enzyme lysyl oxidase to form collagen fibrils
Granulation
Dense population of blood vessels,macrophages, and fibroblasts embedded within a loose provisional matrix of fibronectin, hyaluronic acid, and collagen
Be present in open wounds
Beefy-red appearance
Rich bed of new capillary networks that form by endothelial cell division and migration
VEGF be secreted by Platelet, activated macrophage, and fibroblast
Epithelialization
Epidermal cell layer thickens and marginal basal cells migrate over the wound defect within hours after injury
New epithelial cells for wound closure are provided by fixed basal cells in a zone near the edge of the wound
Their daughter cells flatten and migration over the wound matrix as a sheet
Keratinocytes become columnar and divide to restore the layering of the epidermis and re-form a barrier to further contamination and moisture loss