소개글
[생명공학] Stem cells as cellular delivery vehicles for targeting drugs at tumor site(영문)에 대한 자료입니다.
목차
Introduction
Interesting facts and novel approaches
A. Using neural stem cells to target cancer cells
B. Using mesenchymal stem cells to target cancer cells
Limitations and Solutions
A. Limitations
B. Solutions
Conclusion
References
본문내용
A. Limitations
So far we have seen a new approach of using stem cells for targeting cancer site and a new concept of
treatment. However it might seem fascinating, it is important to note that significant impediments remain
before the true potential of this novel therapy can be fully realized. Here in this section we are going to
mainly focus on the limitations of neural stem cells especially.
First of all, we can raise a question on its efficacy. To make this new concept of curing cancer to be
widely available, a high NSC/tumor cell ratio certainly seems to be a crucial problem to be solved in the
near future. For instance, one group transduced a murine NSC line ex vivo to express an enzyme, then
implanted the transduced NSCs along with a rat glioma cell line intracerebrally into nude mice. A
therapeutic effect was observed, but it required a 1:2 ratio of NSCs to glioma cells. Another group of
investigators similarly implanted murine glioma cells mixed with murine neural stem cells transduced to
express interleukin-4 into syngeneic hosts, with 80% long-term survival compared with 40% with
nontransduced NSCs and none for controls. Both of these studies involved simultaneous inoculation of
tumor and NSCs with a high NSC/tumor cell ratio, therefore an artificial and nonclinically translatable
strategy.
참고문헌
Neural stem cells display extensive tropism for pathology in adult brain: evidence fr
om intracranial gliomas. Proc Natl Acad Sci U S A.
B io l u mi n es c e n c e
i m ag i ng :
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t ar g e t s
Nature Medicine
Metastatic Cancer: Fatal Attraction? PLoS Med. 2006 December; 3(12): e482.
Gene therapy of experimental brain tumors using neural progenitor cells. Nat Med
Gene therapy: can neural stem cells deliver? Nat. Rev. Neuro.
Interleukin-23?Expressing Bone Marrow?Derived Neural Stem-Like Cells Exhibit A
ntitumor Activity against Intracranial Glioma
Region-Specific Apoptosis Limits Neural Stem Cell Proliferation
The glial identity of neural stem cells Nature Neuroscience