![[대사조절학] PPARs-1](http://images.happyhaksul.com/thumb/488/487483-0001.gif)
![[대사조절학] PPARs-2](http://images.happyhaksul.com/thumb/488/487483-0002.gif)
![[대사조절학] PPARs-3](http://images.happyhaksul.com/thumb/488/487483-0003.gif)
![[대사조절학] PPARs-4](http://images.happyhaksul.com/thumb/488/487483-0004.gif)
![[대사조절학] PPARs-5](http://images.happyhaksul.com/thumb/488/487483-0005.gif)
![[대사조절학] PPARs-6](http://images.happyhaksul.com/thumb/488/487483-0006.gif)
![[대사조절학] PPARs-7](http://images.happyhaksul.com/thumb/488/487483-0007.gif)
![[대사조절학] PPARs-8](http://images.happyhaksul.com/thumb/488/487483-0008.gif)
![[대사조절학] PPARs-9](http://images.happyhaksul.com/thumb/488/487483-0009.gif)
![[대사조절학] PPARs-10](http://images.happyhaksul.com/thumb/488/487483-0010.gif)
![[대사조절학] PPARs-11](http://images.happyhaksul.com/thumb/488/487483-0011.gif)
![[대사조절학] PPARs-12](http://images.happyhaksul.com/thumb/488/487483-0012.gif)
![[대사조절학] PPARs-13](http://images.happyhaksul.com/thumb/488/487483-0013.gif)
![[대사조절학] PPARs-14](http://images.happyhaksul.com/thumb/488/487483-0014.gif)
![[대사조절학] PPARs-15](http://images.happyhaksul.com/thumb/488/487483-0015.gif)
![[대사조절학] PPARs-16](http://images.happyhaksul.com/thumb/488/487483-0016.gif)
![[대사조절학] PPARs-17](http://images.happyhaksul.com/thumb/488/487483-0017.gif)
![[대사조절학] PPARs-18](http://images.happyhaksul.com/thumb/488/487483-0018.gif)
![[대사조절학] PPARs-19](http://images.happyhaksul.com/thumb/488/487483-0019.gif)
![[대사조절학] PPARs-20](http://images.happyhaksul.com/thumb/488/487483-0020.gif)
분야
pptPPARs
Four Functional domains of PPARs
Gene transcription mechanisms of PPAR
Pharmacology and PPAR modulators
PPAR γ
The gene of PPAR γ
The ligands of PPAR γ
The Biological effects of PPAR γ
PPAR γ & adiopocyte
PPAR γ - insulin & body weight
PPARγ - macrophages & inflammation
PPARγ - cancer
PPARα
Begining
Hypothesis
Result
PPARδ
PPARδ actions
Regulation of Energy homeostasis
ligands
conclusion
Over View of metabolic roles of the 3 PPARs
PPAR γ and PPAR α
PPAR γ & obesity
Conclusion
Reference
PPARα is increased during the rapid loss of fat
An Experiment of PPARα+/+ and PPARα-/- mice
→ Food intake and weight are reduced in both mice
but fat is reduced only in PPARα+/+
Under the Hyperleptinemia condition fat disappears in 7 days without any relation which is about quantity of free FA or ketone
→ Thus WAT is transformed to Fat burning cells
Expression of PPARα causes leptin action by up-regulating of carnitine palmitoyl transferase(CPT)-1 and acyl CoA oxidase(ACO) which are target enzyme of FA oxidation
It can be considered on that fact that in the WAT expression of PPARα is occurred but in the PPARα -/- condition expression of PPARα mRNA is not occurred.
PPARα+/+
PPARα-/-
Apetite 3
Decreased(32%)
Decreased(37%)
Weight
Decreased(8%)
Decreased(10%)
epididymal fat pad 200mg to 90mg
(55% reduced) 300mg to 280mg
(6% reduced)
Liver TG
Decreased(39%)
Unchanged
Plasma TG
Decreased(34%)
Unchanged
김영설(1998),PPAR과 지질대사,대한내분비학회지,제13권 제3호,303~307
함정엽,원동환,강헌중(2003),PPARδ기능과 리간드의 이해,대한내분비학회지,제18권 제3호,239~249
김용성(1999),비만과PPAR,대한비만학회지,8권1호,17~19
박경수,PPAR γ와 당뇨병,제17차 춘계학술대회,21~27
박경수(1997),PPAR γ와 인슐린 저항성,당뇨병,제21권 제4호,346~351
Sung Sik Choe et al.,Multiple Roles of PPARs and LXRs in Lipid Dysregulation and Metabolic Diseases,제19차 대한 당뇨병학회 춘계학술대회,166
오승준 외(2000),인슐린 비의존형 당뇨병 및 비만증 환자에서의 PPAR γ2 유전자 다형성,대한내과학회지, 제59권 제2호,132~141
이문규(2000),제2형 당뇨병 및 비만증 환자에서의 PPAR γ2 유전자 다형성, 대한내과과학지,제59권 제2호,129~131
차봉수(2001),Role of PPAR γ,대한비만학회지,10권3호,181~185
Sander Kersten, Beatrice Desvergne, Walter Wahli(2000),Roles of PPARs in health and disease,NATURE,VOL405,421~424
Oxana P. Lazarenko et al.(2006),Netoglitazone is a PPAR-γ ligand with selective effects on bond and fat,NIH Public Access,38(1),74~84
Bhavani Prasad Kota, Tom Hsun-Wei Huang, Basil D Roufogalis(2005),An overview on biological mechanisms of PPARs,Pharmacological Reserch,VOL51,85~94
Vasudhevan T. Chetty, Arya M. Sharma(2006),Can PPAR γ agonists have a role in the management of obesity-related hypertension?,Vascular Pharmacology,VOL45,46~53
Arya M. Sharma,Bart Staels(2007),REVIEW:Peroxisome Proliferator-Activated Receptor γand Adipose Tissue – Understanding Obesity-Related Changes in Regulation of Lipid and Glucose MEtabolism,The Journal of Clinical Endocrinology&Metabolism,VOL92,386~395
Robert K. semple, V.Krishna K. Chatterjee, Stephene O’Rahilly(2006),PPAR γ and human metabolic disease,The Journal of Clinical Investigation,VOL116,581~589
Y.Lee et al.(2002), PPARα is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue,PNAS,VOL99,11848~11853
Andrew C. Li et al.(2004),Differential inhibition of macrophage foam-cell formation and atherosclerosis in mice by PPARα, β/δ, γ, The Journal of Clinical Investigation, VOL114, 1564~1576
Annemieke Ijpenberg et al. (2004),In vivo activation of PPAR target genes by RXR homodimers,The EMBO Journal,VOL23,2083~2091
Robert S. Rosenson, MD(2007),Effects of Peroxisome Proliferator-Activated Receptors on Lipoprotein Metabolism and Glucose Control in Type 2 Diabetes Mellitus,The American Journal of Cardiology,VOL99,96B~104B
